StroomaLab • UB

Publications

Journal articles and book chapters.

Journal articles

2025

  1. Alejandro Bernardo, Natalia Díaz-Valdivia, Patricia Fernández-Nogueira, Jordi Alcaraz. Stromagenesis and Cancer-Associated Fibroblast Heterogeneity in Primary Tumors and Metastasis: Focus in Non-Small Cell Lung Cancer FEBS Open Bio. DOI

2024

  1. Paula Duch, Natalia Díaz-Valdivia, Marta Gabasa, Rafael Ikemori, Marselina Arshakyan, Patricia Fernández-Nogueira, Alejandro Llorente, Cristina Teixido, Josep Ramírez, Javier Pereda, Lourdes Chuliá-Peris, José Galbis, Frank Hilberg, Noemí Reguart, Derek Radisky, Jordi Alcaraz. Aberrant TIMP-1 Production in Tumor-Associated Fibroblasts Drives the Selective Benefits of Nintedanib in Lung Adenocarcinoma Cancer Science. DOI PubMed
  2. Alejandro Rosell, Agata Krygowska, Marta Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Alberto Berral-González, Ana Carreras-González, Ottilie Swinyard, Enrique Gabandé-Rodriguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier Rivas, Pedro Cutillas, Esther Castellano. RAS-p110a Signalling in Macrophages Is Required for Effective Inflammatory Response and Resolution of Inflammation eLife. DOI

2023

  1. Enrico Almici, Marselina Arshakyan, Josep Carrasco, Andrea Martínez, Josep Ramírez, Ana Enguita, Eduard Monsó, Joan Montero, Josep Samitier, Jordi Alcaraz. Quantitative Image Analysis of Fibrillar Collagens Reveals Novel Diagnostic and Prognostic Biomarkers and Histotype-Dependent Aberrant Mechanobiology in Lung Cancer Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc. DOI PubMed
  2. Yago Juste-Lanas, Natalia Díaz-Valdivia, Alejandro Llorente, Rafael Ikemori, Alejandro Bernardo, Marselina Arshakyan, Carlos Borau, Josep Ramírez, José Ruffinelli, Ernest Nadal, Noemí Reguart, José García-Aznar, Jordi Alcaraz. 3D Collagen Migration Patterns Reveal a SMAD3-dependent and TGF-β1-independent Mechanism of Recruitment for Tumour-Associated Fibroblasts in Lung Adenocarcinoma British Journal of Cancer. DOI PubMed
  3. Maria Narciso, África Martínez, Constança Júnior, Natalia Díaz-Valdivia, Anna Ulldemolins, Massimiliano Berardi, Kate Neal, Daniel Navajas, Ramon Farré, Jordi Alcaraz, Isaac Almendros, Núria Gavara. Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin Cancers. DOI PubMed

2022

  1. Lourdes Chuliá-Peris, Cristina Carreres-Rey, Marta Gabasa, Jordi Alcaraz, Julián Carretero, Javier Pereda. Matrix Metalloproteinases and Their Inhibitors in Pulmonary Fibrosis: EMMPRIN/CD147 Comes into Play International Journal of Molecular Sciences. DOI PubMed
  2. Paula Duch, Natalia Díaz-Valdivia, Rafael Ikemori, Marta Gabasa, Evette Radisky, Marselina Arshakyan, Sabrina Gea-Sorlí, Anna Mateu-Bosch, Paloma Bragado, Josep Carrasco, Hidetoshi Mori, Josep Ramírez, Cristina Teixidó, Noemí Reguart, Cristina Fillat, Derek Radisky, Jordi Alcaraz. Aberrant TIMP-1 Overexpression in Tumor-Associated Fibroblasts Drives Tumor Progression through CD63 in Lung Adenocarcinoma Matrix Biology: Journal of the International Society for Matrix Biology. DOI PubMed

2021

  1. Jordi Alcaraz, Rafael Ikemori, Alejandro Llorente, Natalia Díaz-Valdivia, Noemí Reguart, Miguel Vizoso. Epigenetic Reprogramming of Tumor-Associated Fibroblasts in Lung Cancer: Therapeutic Opportunities Cancers. DOI PubMed
  2. Marta Gabasa, Evette Radisky, Rafael Ikemori, Giulia Bertolini, Marselina Arshakyan, Alexandra Hockla, Paula Duch, Ornella Rondinone, Alejandro Llorente, Maria Maqueda, Albert Davalos, Elena Gavilán, Alexandre Perera, Josep Ramírez, Pere Gascón, Noemí Reguart, Luca Roz, Derek Radisky, Jordi Alcaraz. MMP1 Drives Tumor Progression in Large Cell Carcinoma of the Lung through Fibroblast Senescence Cancer Letters. DOI PubMed

2020

  1. Marta Gabasa, Marselina Arshakyan, Alejandro Llorente, Lourdes Chuliá-Peris, Irina Pavelescu, Antoni Xaubet, Javier Pereda, Jordi Alcaraz. Interleukin-1β Modulation of the Mechanobiology of Primary Human Pulmonary Fibroblasts: Potential Implications in Lung Repair International Journal of Molecular Sciences. DOI PubMed
  2. Rafael Ikemori, Marta Gabasa, Paula Duch, Miguel Vizoso, Paloma Bragado, Marselina Arshakyan, Iuliana-Cristiana Luis, Albert Marín, Sebastian Morán, Manuel Castro, Gemma Fuster, Sabrina Gea-Sorli, Toni Jauset, Laura Soucek, Luis Montuenga, Manel Esteller, Eduard Monsó, Victor Peinado, Pere Gascon, Cristina Fillat, Frank Hilberg, Noemí Reguart, Jordi Alcaraz. Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma Cancer Research. DOI PubMed
  3. J. Otero, D. Navajas, J. Alcaraz. Characterization of the Elastic Properties of Extracellular Matrix Models by Atomic Force Microscopy Methods in Cell Biology. DOI PubMed

2019

  1. Jordi Alcaraz, Josep Carrasco, Laura Millares, Iuliana-Cristiana Luis, Francisco Fernández-Porras, Anabel Martínez-Romero, Natalia Diaz-Valdivia, Julio De Cos, Ramon Rami-Porta, Luis Seijo, Josep Ramírez, María Pajares, Noemí Reguart, Esther Barreiro, Eduard Monsó. Stromal Markers of Activated Tumor Associated Fibroblasts Predict Poor Survival and Are Associated with Necrosis in Non-Small Cell Lung Cancer Lung Cancer. DOI PubMed
  2. Esther Marhuenda, Noelia Campillo, Marta Gabasa, Miguel Martínez-García, Francisco Campos-Rodríguez, David Gozal, Daniel Navajas, Jordi Alcaraz, Ramon Farré, Isaac Almendros. Effects of Sustained and Intermittent Hypoxia on Human Lung Cancer Cells American Journal of Respiratory Cell and Molecular Biology. DOI PubMed
  3. Laura Sala, Héctor Franco-Valls, Jelena Stanisavljevic, Josue Curto, Jordi Vergés, Raúl Peña, Paula Duch, Jordi Alcaraz, Antonio García de Herreros, Josep Baulida. Abrogation of Myofibroblast Activities in Metastasis and Fibrosis by Methyltransferase Inhibition International Journal of Cancer. DOI PubMed

2018

  1. Jordi Alcaraz, Jorge Otero, Ignasi Jorba, Daniel Navajas. Bidirectional Mechanobiology between Cells and Their Local Extracellular Matrix Probed by Atomic Force Microscopy Seminars in Cell & Developmental Biology. DOI PubMed

2017

  1. Marta Gabasa, Paula Duch, Ignasi Jorba, Alícia Giménez, Roberto Lugo, Irina Pavelescu, Fernando Rodríguez-Pascual, Maria Molina-Molina, Antoni Xaubet, Javier Pereda, Jordi Alcaraz. Epithelial Contribution to the Profibrotic Stiff Microenvironment and Myofibroblast Population in Lung Fibrosis Molecular Biology of the Cell. DOI PubMed
  2. M. Gabasa, R. Ikemori, F. Hilberg, N. Reguart, J. Alcaraz. Nintedanib Selectively Inhibits the Activation and Tumour-Promoting Effects of Fibroblasts from Lung Adenocarcinoma Patients British Journal of Cancer. DOI PubMed
  3. Alícia Giménez, Paula Duch, Marta Puig, Marta Gabasa, Antoni Xaubet, Jordi Alcaraz. Dysregulated Collagen Homeostasis by Matrix Stiffening and TGF-β1 in Fibroblasts from Idiopathic Pulmonary Fibrosis Patients: Role of FAK/Akt International Journal of Molecular Sciences. DOI PubMed
  4. Alícia Giménez, Juan Uriarte, Joan Vieyra, Daniel Navajas, Jordi Alcaraz. Elastic Properties of Hydrogels and Decellularized Tissue Sections Used in Mechanobiology Studies Probed by Atomic Force Microscopy Microscopy Research and Technique. DOI PubMed
  5. Anna Labernadie, Takuya Kato, Agustí Brugués, Xavier Serra-Picamal, Stefanie Derzsi, Esther Arwert, Anne Weston, Victor González-Tarragó, Alberto Elosegui-Artola, Lorenzo Albertazzi, Jordi Alcaraz, Pere Roca-Cusachs, Erik Sahai, Xavier Trepat. A Mechanically Active Heterotypic E-cadherin/N-cadherin Adhesion Enables Fibroblasts to Drive Cancer Cell Invasion Nature Cell Biology. DOI

2016

  1. Roberto Lugo, Marta Gabasa, Francesca Andriani, Marta Puig, Federica Facchinetti, Josep Ramírez, Abel Gómez-Caro, Ugo Pastorino, Gemma Fuster, Isaac Almendros, Pere Gascón, Albert Davalos, Noemí Reguart, Luca Roz, Jordi Alcaraz. Heterotypic Paracrine Signaling Drives Fibroblast Senescence and Tumor Progression of Large Cell Carcinoma of the Lung Oncotarget. DOI PubMed

2015

  1. Eduard Monsó, Luis Montuenga, Julio Sánchez de Cos, Cristina Villena, Lung Cancer CIBERES-RTICC-SEPAR-Plataforma Biobanco Pulmonar. Biological Marker Analysis as Part of the CIBERES-RTIC Cancer-SEPAR Strategic Project on Lung Cancer Archivos De Bronconeumologia. DOI PubMed
  2. Marta Puig, Roberto Lugo, Marta Gabasa, Alícia Giménez, Adriana Velásquez, Roland Galgoczy, Josep Ramírez, Abel Gómez-Caro, Óscar Busnadiego, Fernando Rodríguez-Pascual, Pere Gascón, Noemí Reguart, Jordi Alcaraz. Matrix Stiffening and β1 Integrin Drive Subtype-Specific Fibroblast Accumulation in Lung Cancer Molecular cancer research: MCR. DOI PubMed
  3. Vanesa Vicens-Zygmunt, Susanna Estany, Adai Colom, Ana Montes-Worboys, Carlos Machahua, Andrea Sanabria, Roger Llatjos, Ignacio Escobar, Frederic Manresa, Jordi Dorca, Daniel Navajas, Jordi Alcaraz, Maria Molina-Molina. Fibroblast Viability and Phenotypic Changes within Glycated Stiffened Three-Dimensional Collagen Matrices Respiratory Research. DOI PubMed
  4. Miguel Vizoso, Marta Puig, F. Carmona, María Maqueda, Adriana Velásquez, Antonio Gómez, Anna Labernadie, Roberto Lugo, Marta Gabasa, Luis Rigat-Brugarolas, Xavier Trepat, Josep Ramírez, Sebastian Moran, Enrique Vidal, Noemí Reguart, Alexandre Perera, Manel Esteller, Jordi Alcaraz. Aberrant DNA Methylation in Non-Small Cell Lung Cancer-Associated Fibroblasts Carcinogenesis. DOI PubMed

2014

  1. Adai Colom, Roland Galgoczy, Isaac Almendros, Antonio Xaubet, Ramon Farré, Jordi Alcaraz. Oxygen Diffusion and Consumption in Extracellular Matrix Gels: Implications for Designing Three-Dimensional Cultures Journal of Biomedical Materials Research. Part A. DOI PubMed
  2. Roland Galgoczy, Isabel Pastor, Adai Colom, Alicia Giménez, Francesc Mas, Jordi Alcaraz. A Spectrophotometer-Based Diffusivity Assay Reveals That Diffusion Hindrance of Small Molecules in Extracellular Matrix Gels Used in 3D Cultures Is Dominated by Viscous Effects Colloids and Surfaces. B, Biointerfaces. DOI PubMed

2013

  1. Hidetoshi Mori, Alvin Lo, Jamie Inman, Jordi Alcaraz, Cyrus Ghajar, Joni Mott, Celeste Nelson, Connie Chen, Hui Zhang, Jamie Bascom, Motoharu Seiki, Mina Bissell. Transmembrane/Cytoplasmic, Rather than Catalytic, Domains of Mmp14 Signal to MAPK Activation and Mammary Branching Morphogenesis via Binding to Integrin β1 Development. DOI PubMed

2012

  1. Irene Acerbi, Tomás Luque, Alícia Giménez, Marta Puig, Noemi Reguart, Ramon Farré, Daniel Navajas, Jordi Alcaraz. Integrin-Specific Mechanoresponses to Compression and Extension Probed by Cylindrical Flat-Ended AFM Tips in Lung Cells PLOS ONE. DOI

2011

  1. Jordi Alcaraz, Hidetoshi Mori, Cyrus Ghajar, Doug Brownfield, Roland Galgoczy, Mina Bissell. Collective Epithelial Cell Invasion Overcomes Mechanical Barriers of Collagenous Extracellular Matrix by a Narrow Tube-like Geometry and MMP14-dependent Local Softening Integrative Biology: Quantitative Biosciences from Nano to Macro. DOI PubMed

2008

  1. Jordi Alcaraz, Ren Xu, Hidetoshi Mori, Celeste Nelson, Rana Mroue, Virginia Spencer, Doug Brownfield, Derek Radisky, Carlos Bustamante, Mina Bissell. Laminin and Biomimetic Extracellular Elasticity Enhance Functional Differentiation in Mammary Epithelia The EMBO Journal. DOI PubMed
  2. Pere Roca-Cusachs, Jordi Alcaraz, Raimon Sunyer, Josep Samitier, Ramon Farré, Daniel Navajas. Micropatterning of Single Endothelial Cell Shape Reveals a Tight Coupling between Nuclear Volume in G1 and Proliferation Biophysical Journal. DOI PubMed

2007

  1. Johanne Le Beyec, Ren Xu, Sun-Young Lee, Celeste Nelson, Aylin Rizki, Jordi Alcaraz, Mina Bissell. Cell Shape Regulates Global Histone Acetylation in Human Mammary Epithelial Cells Experimental Cell Research. DOI PubMed

2005

  1. Alcaraz J. Nanomechanics of lung epithelial cells

2004

  1. Jordi Alcaraz, Celeste Nelson, Mina Bissell. Biomechanical Approaches for Studying Integration of Tissue Structure and Function in Mammary Epithelia Journal of Mammary Gland Biology and Neoplasia. DOI PubMed

2003

  1. Jordi Alcaraz, Lara Buscemi, Mireia Grabulosa, Xavier Trepat, Ben Fabry, Ramon Farré, Daniel Navajas. Microrheology of Human Lung Epithelial Cells Measured by Atomic Force Microscopy Biophysical Journal. DOI PubMed

2002

  1. Jordi Alcaraz, Lara Buscemi, Marina Marinkovic, Jaime Colchero, Arturo Baró, Daniel Navajas. Correction of Microrheological Measurements of Soft Samples with Atomic Force Microscopy for the Hydrodynamic Drag on the Cantilever Langmuir. DOI

2001

  1. M. Puig-De-Morales, M. Grabulosa, J. Alcaraz, J. Mullol, G. Maksym, J. Fredberg, D. Navajas. Measurement of Cell Microrheology by Magnetic Twisting Cytometry with Frequency Domain Demodulation Journal of Applied Physiology. DOI PubMed

2000

  1. D. Navajas, J. Alcaraz, R. Peslin, J. Roca, R. Farré. Evaluation of a Method for Assessing Respiratory Mechanics during Noninvasive Ventilation The European Respiratory Journal. DOI PubMed

Book chapters